Gene information
Official symbol MBL2
Official full name mannose binding lectin 2
Gene type protein-coding gene
Chromosome10q21.1
Alias symbolCOLEC1
Previous symbolMBL
Gene familyCollectins; Complement system activation components
Resources
Entrez Gene 4153
HGNC HGNC:6922
Ensembl ENSG00000165471
Vega OTTHUMG00000150270
UCSC uc001jjt.3
GO terms: 51 records
GO Description Category LogP Number of genes Detail
GO:0001867 complement activation, lectin pathway GO Biological Processes -3.60391289 3 More
GO:0002218 activation of innate immune response GO Biological Processes -2.02855230 4 More
GO:0002221 pattern recognition receptor signaling pathway GO Biological Processes -6.97185167 18 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002253 activation of immune response GO Biological Processes -3.86084748 14 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002449 lymphocyte mediated immunity GO Biological Processes -8.72662877 18 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002526 acute inflammatory response GO Biological Processes -34.5980034 29 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002699 positive regulation of immune effector process GO Biological Processes -18.3926498 29 More
GO:0002764 immune response-regulating signaling pathway GO Biological Processes -3.80325753 14 More
GO:0002831 regulation of response to biotic stimulus GO Biological Processes -10.931136 25 More
GO:0002833 positive regulation of response to biotic stimulus GO Biological Processes -5.95822718 13 More
GO:0005581 collagen trimer GO Cellular Components -6.28484906 16 More
GO:0006953 acute-phase response GO Biological Processes -24.9631834 19 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006956 complement activation GO Biological Processes -7.12107226 12 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0006979 response to oxidative stress GO Biological Processes -17.6147653 58 More
GO:0008228 opsonization GO Biological Processes -7.69370672 5 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0030246 carbohydrate binding GO Molecular Functions -4.83003123 14 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0045088 regulation of innate immune response GO Biological Processes -6.98001665 16 More
GO:0045089 positive regulation of innate immune response GO Biological Processes -3.90916833 9 More
GO:0048029 monosaccharide binding GO Molecular Functions -1.85122889 4 More
GO:0048306 calcium-dependent protein binding GO Molecular Functions -6.71779738 10 More
GO:0048525 negative regulation of viral process GO Biological Processes -2.82207312 11 More
GO:0050764 regulation of phagocytosis GO Biological Processes -16.0793009 29 More
GO:0050766 positive regulation of phagocytosis GO Biological Processes -13.5971167 15 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050792 regulation of viral process GO Biological Processes -4.90676471 20 More
GO:0050830 defense response to Gram-positive bacterium GO Biological Processes -13.1972375 17 More
GO:0051702 biological process involved in interaction with symbiont GO Biological Processes -12.570571 16 More
GO:0051873 killing by host of symbiont cells GO Biological Processes -7.35623750 7 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:1905286 serine-type peptidase complex GO Cellular Components -11.3739342 10 More
GO:1905368 peptidase complex GO Cellular Components -4.61293625 9 More
GO:1905369 endopeptidase complex GO Cellular Components -3.16416938 6 More
GO:1905370 serine-type endopeptidase complex GO Cellular Components -8.85311859 8 More
KEGG pathways: 4 records
KEGG Description Category LogP Number of genes Detail
hsa04145 Phagosome KEGG Pathway -11.4012504 17 More
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa05150 Staphylococcus aureus infection KEGG Pathway -9.38905356 13 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
danazol NCI 12076401 view
Related studies: 6 records
Molecular factor Omics type Application Objective MI type Reference
MBL2 LYQA secretor haplotype genomics type 5 myocardial infarction[diagnosis] type 5 myocardial infarction Collard CD et al. Circulation. 2007
NM_001378373.1:c.[161G>A;170G>A;154C>T;-9-281C>A] genomics myocardial infarction[diagnosis] myocardial infarction Vengen IT et al. PLoS One. 2012
mannose-binding protein C proteomics myocardial infarction[diagnosis] myocardial infarction Saevarsdottir S et al. J Exp Med. 2005
mannose-binding protein C proteomics subsequent myocardial infarction[prognosis (bad)] acute myocardial infarction Ueland T et al. J Card Fail. 2006
mannose-binding protein C proteomics myocardial infarction[diagnosis] myocardial infarction Troelsen LN et al. Arthritis Rheum. 2007
mannose-binding protein C proteomics poor predictor reduced left ventricular ejection fraction[prognosis (bad)] acute myocardial infarction Haahr-Pedersen S et al. J Invasive Cardiol. 2009
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